6WV5

Human VKOR C43S mutant with vitamin K1 epoxide

6WV5 の概要

• エントリーDOI: 10.2210/pdb6wv5/pdb
• 分子名称: Vitamin K epoxide reductase Cys43Ser mutant, termini restrained by green fluorescent protein, (2R,3R)-2-hydroxy-3-methyl-2-[(2E,7S)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-2,3-dihydronaphthalene-1,4-dione (2 entities in total)
• 機能のキーワード: vitamin k epoxide reductase (vkor), vitamin k, warfarin, superwarfarin, vitamin k expoxide(ko), membrane protein, oxidoreductase, fluorescent protein
• 由来する生物種: Aequorea victoria (Jellyfish); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44650.08

構造登録者

Liu, S.,Sukumar, N.,Li, W. (登録日: 2020-05-05, 公開日: 2020-11-11, 最終更新日: 2023-11-15)

• 主引用文献: Liu, S.,Li, S.,Shen, G.,Sukumar, N.,Krezel, A.M.,Li, W.; Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.; Science, 371:-, 2021; PubMed: 33154105; DOI: 10.1126/science.abc5667

実験手法

X-RAY DIFFRACTION (2.8 Å)