6WUZ

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by GB

6WUZ の概要

• エントリーDOI: 10.2210/pdb6wuz/pdb
• 関連するPDBエントリー: 6WUV 6WUY
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, propan-2-yl hydrogen (S)-methylphosphonate, ... (6 entities in total)
• 機能のキーワード: nerve agent, acetylcholinesterase, tabun, ga, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121413.63

構造登録者

McGuire, J.R.,Bester, S.M.,Pegan, S.D.,Height, J.J. (登録日: 2020-05-05, 公開日: 2021-02-24, 最終更新日: 2023-10-18)

• 主引用文献: McGuire, J.R.,Bester, S.M.,Guelta, M.A.,Cheung, J.,Langley, C.,Winemiller, M.D.,Bae, S.Y.,Funk, V.,Myslinski, J.M.,Pegan, S.D.,Height, J.J.; Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6.; Chem.Res.Toxicol., 34:804-816, 2021; PubMed: 33538594; DOI: 10.1021/acs.chemrestox.0c00406

実験手法

X-RAY DIFFRACTION (2.253 Å)