6WTN
Human JAK2 JH1 domain in complex with Ruxolitinib
Summary for 6WTN
Entry DOI | 10.2210/pdb6wtn/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 1,2-ETHANEDIOL, (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, ... (4 entities in total) |
Functional Keywords | phosphorylation, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36904.87 |
Authors | Yu, S.,Nithianantham, S.,Fischer, M. (deposition date: 2020-05-03, release date: 2021-05-05, Last modification date: 2023-11-15) |
Primary citation | Chang, Y.,Min, J.,Jarusiewicz, J.A.,Actis, M.,Yu-Chen Bradford, S.,Mayasundari, A.,Yang, L.,Chepyala, D.,Alcock, L.J.,Roberts, K.G.,Nithianantham, S.,Maxwell, D.,Rowland, L.,Larsen, R.,Seth, A.,Goto, H.,Imamura, T.,Akahane, K.,Hansen, B.S.,Pruett-Miller, S.M.,Paietta, E.M.,Litzow, M.R.,Qu, C.,Yang, J.J.,Fischer, M.,Rankovic, Z.,Mullighan, C.G. Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138:2313-2326, 2021 Cited by PubMed: 34110416DOI: 10.1182/blood.2020006846 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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