6WTJ
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Summary for 6WTJ
Entry DOI | 10.2210/pdb6wtj/pdb |
Descriptor | 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total) |
Functional Keywords | covid-19, sars-cov-2, 3clpro, coronavirus, main protease, kinetics, sars, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 1 |
Total formula weight | 34311.10 |
Authors | Khan, M.B.,Arutyunova, E.,Young, H.S.,Lemieux, M.J. (deposition date: 2020-05-02, release date: 2020-05-20, Last modification date: 2023-10-18) |
Primary citation | Vuong, W.,Khan, M.B.,Fischer, C.,Arutyunova, E.,Lamer, T.,Shields, J.,Saffran, H.A.,McKay, R.T.,van Belkum, M.J.,Joyce, M.A.,Young, H.S.,Tyrrell, D.L.,Vederas, J.C.,Lemieux, M.J. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nat Commun, 11:4282-4282, 2020 Cited by PubMed: 32855413DOI: 10.1038/s41467-020-18096-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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