6WT4

Structure of a bacterial STING receptor from Flavobacteriaceae sp. in complex with 3',3'-cGAMP

6WT4 の概要

• エントリーDOI: 10.2210/pdb6wt4/pdb
• 分子名称: Bacterial STING, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: cbass, cyclic dinucleotide receptor, cd-ntase, immune effector, immune system
• 由来する生物種: Flavobacteriaceae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38205.29

構造登録者

Morehouse, B.R.,Govande, A.A.,Millman, A.,Keszei, A.F.A.,Lowey, B.,Ofir, G.,Shao, S.,Sorek, R.,Kranzusch, P.J. (登録日: 2020-05-01, 公開日: 2020-09-09, 最終更新日: 2020-10-28)

• 主引用文献: Morehouse, B.R.,Govande, A.A.,Millman, A.,Keszei, A.F.A.,Lowey, B.,Ofir, G.,Shao, S.,Sorek, R.,Kranzusch, P.J.; STING cyclic dinucleotide sensing originated in bacteria.; Nature, 586:429-433, 2020; PubMed: 32877915; DOI: 10.1038/s41586-020-2719-5

実験手法

X-RAY DIFFRACTION (1.78 Å)