6WSI
Intact cis-2,3-epoxysuccinic acid bound to Isocitrate Lyase-1 from Mycobacterium tuberculosis
Summary for 6WSI
Entry DOI | 10.2210/pdb6wsi/pdb |
Descriptor | Isocitrate lyase, MAGNESIUM ION, GLYOXYLIC ACID, ... (7 entities in total) |
Functional Keywords | enzyme, covalent inhibitor, substrate analog, structural genomics, psi-biology, tb structural genomics consortium, tbsgc, lyase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 191284.25 |
Authors | Krieger, I.V.,Mellott, D.,Meek, T.D.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2020-05-01, release date: 2021-03-24, Last modification date: 2023-10-18) |
Primary citation | Pham, T.V.,Mellott, D.M.,Moghadamchargari, Z.,Chen, K.,Krieger, I.,Laganowsky, A.,Sacchettini, J.C.,Meek, T.D. Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis -2,3-Epoxy-Succinic Acid. Acs Chem.Biol., 16:463-470, 2021 Cited by PubMed: 33688722DOI: 10.1021/acschembio.0c00740 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.749 Å) |
Structure validation
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