6WS1

Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)propyl)amino)butanoic acid and AdoHcy (SAH)

6WS1 の概要

• エントリーDOI: 10.2210/pdb6ws1/pdb
• 分子名称: Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: transition state analogue, chemical synthesis, drug design, structural biology, neurodegenerative disease, pnmt, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65986.80

構造登録者

Harijan, R.K.,Mahmoodi, N.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (登録日: 2020-04-30, 公開日: 2020-08-05, 最終更新日: 2023-10-18)

• 主引用文献: Mahmoodi, N.,Harijan, R.K.,Schramm, V.L.; Transition-State Analogues of PhenylethanolamineN-Methyltransferase.; J.Am.Chem.Soc., 142:14222-14233, 2020; PubMed: 32702980; DOI: 10.1021/jacs.0c05446

実験手法

X-RAY DIFFRACTION (2.76 Å)