6WS0
Rational drug design of phenazopyridine derivatives as novel inhibitors of Rev1-CT
This is a non-PDB format compatible entry.
Summary for 6WS0
| Entry DOI | 10.2210/pdb6ws0/pdb |
| Descriptor | DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, DNA polymerase zeta catalytic subunit, ... (4 entities in total) |
| Functional Keywords | scaffold, translesion synethesis, dna damage response, dna damage tolerance, protein binding-transferase complex, protein binding/transferase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 42745.22 |
| Authors | McPherson, K.S.,Korzhnev, D.M. (deposition date: 2020-04-30, release date: 2020-12-23, Last modification date: 2023-10-18) |
| Primary citation | McPherson, K.S.,Zaino, A.M.,Dash, R.C.,Rizzo, A.A.,Li, Y.,Hao, B.,Bezsonova, I.,Hadden, M.K.,Korzhnev, D.M. Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis. Chemmedchem, 16:1126-1132, 2021 Cited by PubMed: 33314657DOI: 10.1002/cmdc.202000893 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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