6WIN

Type 6 secretion amidase effector 2 (Tae2)

6WIN の概要

• エントリーDOI: 10.2210/pdb6win/pdb
• 分子名称: Type 6 secretion amidase effector 2 (2 entities in total)
• 機能のキーワード: amidase, toxin, peptidoglycan hydrolase, antimicrobial protein
• 由来する生物種: Salmonella typhi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15986.51

構造登録者

Chou, S.,Radkov, A.D. (登録日: 2020-04-10, 公開日: 2020-04-22, 最終更新日: 2024-10-23)

主引用文献

Hayes, B.M.,Radkov, A.D.,Yarza, F.,Flores, S.,Kim, J.,Zhao, Z.,Lexa, K.W.,Marnin, L.,Biboy, J.,Bowcut, V.,Vollmer, W.,Pedra, J.H.F.,Chou, S.
Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin.
Cell, 183:1562-1571.e12, 2020

PubMed Abstract: Ticks transmit a diverse array of microbes to vertebrate hosts, including human pathogens, which has led to a human-centric focus in this vector system. Far less is known about pathogens of ticks themselves. Here, we discover that a toxin in blacklegged ticks (Ixodes scapularis) horizontally acquired from bacteria-called domesticated amidase effector 2 (dae2)-has evolved to kill mammalian skin microbes with remarkable efficiency. Secreted into the saliva and gut of ticks, Dae2 limits skin-associated staphylococci in ticks while feeding. In contrast, Dae2 has no intrinsic ability to kill Borrelia burgdorferi, the tick-borne Lyme disease bacterial pathogen. These findings suggest ticks resist their own pathogens while tolerating symbionts. Thus, just as tick symbionts can be pathogenic to humans, mammalian commensals can be harmful to ticks. Our study underscores how virulence is context-dependent and bolsters the idea that "pathogen" is a status and not an identity.

PubMed: 33306955
DOI: 10.1016/j.cell.2020.10.042

実験手法

X-RAY DIFFRACTION (2.05 Å)