6WHM

The crystal structure of the 2009/H1N1/California PA endonuclease wild type bound to DNA oligomer TAGC (cleaved TTAGCATT, 5mM overnight DNA soak)

6WHM の概要

• エントリーDOI: 10.2210/pdb6whm/pdb
• 分子名称: PA-X protein,Polymerase acidic protein, DNA (5'-D(P*TP*AP*GP*C)-3'), GLYCEROL, ... (7 entities in total)
• 機能のキーワード: nuclease, influenza, dna oligomer, cleaved, viral protein, viral protein-dna complex, dna binding protein, viral protein/dna
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26044.82

構造登録者

Cuypers, M.G.,Kumar, G.,Webb, T.,White, S.W. (登録日: 2020-04-08, 公開日: 2021-02-03, 最終更新日: 2023-10-18)

• 主引用文献: Kumar, G.,Cuypers, M.,Webby, R.R.,Webb, T.R.,White, S.W.; Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism.; Nucleic Acids Res., 49:1609-1618, 2021; PubMed: 33469660; DOI: 10.1093/nar/gkaa1294

実験手法

X-RAY DIFFRACTION (1.92 Å)