6WHA

HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)

6WHA の概要

• エントリーDOI: 10.2210/pdb6wha/pdb
• EMDBエントリー: 21669
• 分子名称: Soluble cytochrome b562,5-hydroxytryptamine receptor 2A chimera, G subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• 機能のキーワード: 5ht2a, g protein, 25-cn-nboh, gpcr, cryo-em, membrane protein-immune system complex, membrane protein/immune system
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 160512.66

構造登録者

Skiniotis, G.,Roth, B.,Kim, K.,Panova, O. (登録日: 2020-04-07, 公開日: 2020-09-23)

• 主引用文献: Kim, K.,Che, T.,Panova, O.,Shoichet, B.K.,Skiniotis, G.,Roth, B.L.; Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor; Cell(Cambridge,Mass.), 182:1574-1588, 2020; DOI: 10.1016/j.cell.2020.08.024

実験手法

ELECTRON MICROSCOPY (3.36 Å)