6WFG

Crystal structure of human Naa50 in complex with an inhibitor (compound 3) identified using DNA encoded library technology

6WFG の概要

• エントリーDOI: 10.2210/pdb6wfg/pdb
• 関連するPDBエントリー: 6WF3 6WF5
• 分子名称: N-alpha-acetyltransferase 50, COENZYME A, (2S)-N-[(2S)-3-[1-(3-tert-butyl-1-methyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]-1-(methylamino)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: n-alpha-acetyltransferase 50, inhibitor complex, dna encoded library, coa, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 62440.90

構造登録者

Greasley, S.E.,Feng, J.,Deng, Y.-L.,Stewart, A.E. (登録日: 2020-04-03, 公開日: 2020-07-01, 最終更新日: 2024-03-06)

• 主引用文献: Kung, P.P.,Bingham, P.,Burke, B.J.,Chen, Q.,Cheng, X.,Deng, Y.L.,Dou, D.,Feng, J.,Gallego, G.M.,Gehring, M.R.,Grant, S.K.,Greasley, S.,Harris, A.R.,Maegley, K.A.,Meier, J.,Meng, X.,Montano, J.L.,Morgan, B.A.,Naughton, B.S.,Palde, P.B.,Paul, T.A.,Richardson, P.,Sakata, S.,Shaginian, A.,Sonnenburg, W.K.,Subramanyam, C.,Timofeevski, S.,Wan, J.,Yan, W.,Stewart, A.E.; Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.; Acs Med.Chem.Lett., 11:1175-1184, 2020; PubMed: 32550998; DOI: 10.1021/acsmedchemlett.0c00029

実験手法

X-RAY DIFFRACTION (2.16 Å)