6WF2

Crystal structure of mouse SCD1 with a diiron center

6WF2 の概要

• エントリーDOI: 10.2210/pdb6wf2/pdb
• 分子名称: Acyl-CoA desaturase 1, FE (III) ION, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) (3 entities in total)
• 機能のキーワード: scd1, membrane enzyme, diiron center, electron transfer, double bond formation, membrane protein, oxidoreductase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81428.60

構造登録者

Shen, J.,Zhou, M. (登録日: 2020-04-03, 公開日: 2020-06-17, 最終更新日: 2023-10-18)

• 主引用文献: Shen, J.,Wu, G.,Tsai, A.L.,Zhou, M.; Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase.; J.Mol.Biol., 432:5152-5161, 2020; PubMed: 32470559; DOI: 10.1016/j.jmb.2020.05.017

実験手法

X-RAY DIFFRACTION (3.51 Å)