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6WEQ

DENV1 NS1 in complex with neutralizing 2B7 Fab fragment

Summary for 6WEQ
Entry DOI10.2210/pdb6weq/pdb
DescriptorNon-structural protein 1, 2B7 Fab fragment heavy chain, 2B7 Fab fragment light chain, ... (5 entities in total)
Functional Keywordsflavivirus ns1, antibody, fab fragment, viral protein
Biological sourceDengue virus 1
More
Total number of polymer chains12
Total formula weight392469.42
Authors
Akey, D.L.,Smith, J.L. (deposition date: 2020-04-02, release date: 2020-12-23, Last modification date: 2023-10-18)
Primary citationBiering, S.B.,Akey, D.L.,Wong, M.P.,Brown, W.C.,Lo, N.T.N.,Puerta-Guardo, H.,Tramontini Gomes de Sousa, F.,Wang, C.,Konwerski, J.R.,Espinosa, D.A.,Bockhaus, N.J.,Glasner, D.R.,Li, J.,Blanc, S.F.,Juan, E.Y.,Elledge, S.J.,Mina, M.J.,Beatty, P.R.,Smith, J.L.,Harris, E.
Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
Science, 371:194-200, 2021
Cited by
PubMed: 33414220
DOI: 10.1126/science.abc0476
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

221051

數據於2024-06-12公開中

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