6WEQ
DENV1 NS1 in complex with neutralizing 2B7 Fab fragment
Summary for 6WEQ
Entry DOI | 10.2210/pdb6weq/pdb |
Descriptor | Non-structural protein 1, 2B7 Fab fragment heavy chain, 2B7 Fab fragment light chain, ... (5 entities in total) |
Functional Keywords | flavivirus ns1, antibody, fab fragment, viral protein |
Biological source | Dengue virus 1 More |
Total number of polymer chains | 12 |
Total formula weight | 392469.42 |
Authors | Akey, D.L.,Smith, J.L. (deposition date: 2020-04-02, release date: 2020-12-23, Last modification date: 2023-10-18) |
Primary citation | Biering, S.B.,Akey, D.L.,Wong, M.P.,Brown, W.C.,Lo, N.T.N.,Puerta-Guardo, H.,Tramontini Gomes de Sousa, F.,Wang, C.,Konwerski, J.R.,Espinosa, D.A.,Bockhaus, N.J.,Glasner, D.R.,Li, J.,Blanc, S.F.,Juan, E.Y.,Elledge, S.J.,Mina, M.J.,Beatty, P.R.,Smith, J.L.,Harris, E. Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science, 371:194-200, 2021 Cited by PubMed: 33414220DOI: 10.1126/science.abc0476 PDB entries with the same primary citation |
Experimental method |
Structure validation
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