6WE5

Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx

6WE5 の概要

• エントリーDOI: 10.2210/pdb6we5/pdb
• 分子名称: Inorganic pyrophosphatase, SODIUM ION (3 entities in total)
• 機能のキーワード: national institute of allergy and infectious diseases, niaid, structural genomics, sexually transmitted infections, sti, std, pyrophosphate phospho-hydrolase, seattle structural genomics center for infectious disease, ssgcid, hydrolase
• 由来する生物種: Chlamydia trachomatis (strain D/UW-3/Cx)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 73409.65

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2020-04-01, 公開日: 2020-04-08, 最終更新日: 2023-10-18)

主引用文献

Maddy, J.,Staker, B.L.,Subramanian, S.,Abendroth, J.,Edwards, T.E.,Myler, P.J.,Hybiske, K.,Asojo, O.A.
Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx.
Acta Crystallogr.,Sect.F, 78:135-142, 2022

PubMed Abstract: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections globally and is one of the most commonly reported infections in the United States. There is a need to develop new therapeutics due to drug resistance and the failure of current treatments to clear persistent infections. Structures of potential C. trachomatis rational drug-discovery targets, including C. trachomatis inorganic pyrophosphatase (CtPPase), have been determined by the Seattle Structural Genomics Center for Infectious Disease. Inorganic pyrophosphatase hydrolyzes inorganic pyrophosphate during metabolism. Furthermore, bacterial inorganic pyrophosphatases have shown promise for therapeutic discovery. Here, a 2.2 Å resolution X-ray structure of CtPPase is reported. The crystal structure of CtPPase reveals shared structural features that may facilitate the repurposing of inhibitors identified for bacterial inorganic pyrophosphatases as starting points for new therapeutics for C. trachomatis.

PubMed: 35234139
DOI: 10.1107/S2053230X22002138

実験手法

X-RAY DIFFRACTION (2.25 Å)