6WCK
KRAS G-quadruplex G16T mutant with Bromo Uracil replacing T8 and T16.
Summary for 6WCK
Entry DOI | 10.2210/pdb6wck/pdb |
Related | 6n65 |
Descriptor | DNA (5'-D(*AP*GP*GP*GP*CP*GP*GP*(BRU)P*GP*TP*GP*GP*GP*AP*AP*(BRU)P*AP*GP*GP*GP*AP*A)-3'), POTASSIUM ION (3 entities in total) |
Functional Keywords | kras, g-quadruplex, promoter sequence, g16t mutant, bromouracil, dna |
Biological source | Homo sapiens |
Total number of polymer chains | 2 |
Total formula weight | 14428.00 |
Authors | Schmidberger, J.W.,Ou, A.,Smith, N.M.,Iyer, K.S.,Bond, C.S. (deposition date: 2020-03-30, release date: 2020-04-15, Last modification date: 2023-10-18) |
Primary citation | Ou, A.,Schmidberger, J.W.,Wilson, K.A.,Evans, C.W.,Hargreaves, J.A.,Grigg, M.,O'Mara, M.L.,Iyer, K.S.,Bond, C.S.,Smith, N.M. High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A pi-stacking interactions for small-molecule recognition. Nucleic Acids Res., 48:5766-5776, 2020 Cited by PubMed: 32313953DOI: 10.1093/nar/gkaa262 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.801 Å) |
Structure validation
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