6WB5
Microbiome-derived Acarbose Kinase Mak1 as a Complex with Acarbose and AMP-PNP
Summary for 6WB5
Entry DOI | 10.2210/pdb6wb5/pdb |
Related | 6WB4 |
Related PRD ID | PRD_900007 |
Descriptor | Acarbose Kinase Mak1, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total) |
Functional Keywords | carbohydrate kinase, acarbose, transferase, nucleotide binding, atp binding, metal ion binding, ribokinase activity, complex |
Biological source | uncultured bacterium |
Total number of polymer chains | 2 |
Total formula weight | 70800.48 |
Authors | Jeffrey, P.D.,Balaich, J.N.,Estrella, M.A.,Donia, M.S. (deposition date: 2020-03-26, release date: 2021-04-21, Last modification date: 2023-10-18) |
Primary citation | Balaich, J.,Estrella, M.,Wu, G.,Jeffrey, P.D.,Biswas, A.,Zhao, L.,Korennykh, A.,Donia, M.S. The human microbiome encodes resistance to the antidiabetic drug acarbose. Nature, 600:110-115, 2021 Cited by PubMed: 34819672DOI: 10.1038/s41586-021-04091-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.102 Å) |
Structure validation
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