6W9Y

De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release

6W9Y の概要

• エントリーDOI: 10.2210/pdb6w9y/pdb
• 分子名称: De novo designed receptor transmembrane domain proMP 1.2, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate (2 entities in total)
• 機能のキーワード: transmembrane domain, de novo design, biosynthetic protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 13517.04

構造登録者

Call, M.J.,Call, M.E.,Chandler, N.J.,Nguyen, J.V.,Trenker, R. (登録日: 2020-03-24, 公開日: 2021-03-31, 最終更新日: 2023-10-18)

• 主引用文献: Elazar, A.,Chandler, N.J.,Davey, A.S.,Weinstein, J.Y.,Nguyen, J.V.,Trenker, R.,Jenkins, M.,Call, M.J.,Call, M.E.,Fleishman, S.J.; De novo designed receptor transmembrane domains enhance CAR-T cytotoxicity and attenuate cytokine release; To Be Published,

実験手法

X-RAY DIFFRACTION (2.55 Å)