6W7O

Ternary complex structure - BTK cIAP compound 17

Summary for 6W7O

• Entry DOI: 10.2210/pdb6w7o/pdb
• Related: 6W74
• Descriptor: Tyrosine-protein kinase BTK, Baculoviral IAP repeat-containing protein 2, [5-({[(3S)-2-(N-methyl-L-alanyl-3-methyl-L-valyl)-3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}methyl)pyrazin-2-yl]methyl (3R)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazol-1-yl}piperidine-1-carboxylate, ... (5 entities in total)
• Functional Keywords: ciap e3 protac, ligase, ligase-transferase complex, ligase/transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 89158.32

Authors

Calabrese, M.F.,Schiemer, J.S. (deposition date: 2020-03-19, release date: 2020-11-18, Last modification date: 2023-10-18)

• Primary citation: Calabrese, M.F.,Schiemer, J.S.,Horst, R.,Meng, Y.,Montgomery, J.,Xu, Y.,Feng, X.,Borzilleri, K.,Uccello, D.P.,Leverett, C.,Brown, S.,Che, Y.,Brown, M.F.,Hayward, M.M.,Gilbert, A.M.,Noe, M.C.; Structural Characterization of BTK:PROTAC:cIAP Ternary Complexes: From Snapshots to Ensembles; Nat.Chem.Biol., 2020

Experimental method

X-RAY DIFFRACTION (2.17 Å)