6W7H

Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments

6W7H の概要

• エントリーDOI: 10.2210/pdb6w7h/pdb
• 分子名称: Nonstructural polyprotein, 6-methyl-2-oxo-2,5-dihydropyrimidine-4-carboxylic acid (3 entities in total)
• 機能のキーワード: nsp3, macrodomain, pyrimidone fragments, viral protein
• 由来する生物種: Chikungunya virus (CHIKV)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 74692.00

構造登録者

Zhang, S.,Garzan, A.,Augelli-Szafran, C.E.,Pathak, A.K.,Wu, M. (登録日: 2020-03-19, 公開日: 2021-01-13, 最終更新日: 2023-10-18)

• 主引用文献: Zhang, S.,Garzan, A.,Haese, N.,Bostwick, R.,Martinez-Gzegozewska, Y.,Rasmussen, L.,Streblow, D.N.,Haise, M.T.,Pathak, A.K.,Augelli-Szafran, C.E.,Wu, M.; Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.; Plos One, 16:e0245013-e0245013, 2021; PubMed: 33482665; DOI: 10.1371/journal.pone.0245013

実験手法

X-RAY DIFFRACTION (1.95 Å)