6W39
Structure of unphosphorylated IRE1 in complex with G-1749
Summary for 6W39
Entry DOI | 10.2210/pdb6w39/pdb |
Descriptor | Serine/threonine-protein kinase/endoribonuclease IRE1, ethyl ~{N}-[6-methyl-5-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxy-naphthalen-1-yl]carbamate (3 entities in total) |
Functional Keywords | kinase, upr, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 99603.68 |
Authors | Ferri, E.,Wang, W.,Joachim, R.,Mortara, K. (deposition date: 2020-03-09, release date: 2020-12-09, Last modification date: 2023-10-18) |
Primary citation | Ferri, E.,Le Thomas, A.,Wallweber, H.A.,Day, E.S.,Walters, B.T.,Kaufman, S.E.,Braun, M.G.,Clark, K.R.,Beresini, M.H.,Mortara, K.,Chen, Y.A.,Canter, B.,Phung, W.,Liu, P.S.,Lammens, A.,Ashkenazi, A.,Rudolph, J.,Wang, W. Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands. Nat Commun, 11:6387-6387, 2020 Cited by PubMed: 33318494DOI: 10.1038/s41467-020-19974-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.736 Å) |
Structure validation
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