6W35
A new Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry
Summary for 6W35
Entry DOI | 10.2210/pdb6w35/pdb |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase 2, IODIDE ION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | autotaxin, lipid binding protein |
Biological source | Pan troglodytes (Chimpanzee) |
Total number of polymer chains | 1 |
Total formula weight | 97774.61 |
Authors | Cuozzo, J.W. (deposition date: 2020-03-09, release date: 2020-07-08, Last modification date: 2023-10-18) |
Primary citation | Cuozzo, J.W.,Clark, M.A.,Keefe, A.D.,Kohlmann, A.,Mulvihill, M.,Ni, H.,Renzetti, L.M.,Resnicow, D.I.,Ruebsam, F.,Sigel, E.A.,Thomson, H.A.,Wang, C.,Xie, Z.,Zhang, Y. Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry. J.Med.Chem., 63:7840-7856, 2020 Cited by PubMed: 32584034DOI: 10.1021/acs.jmedchem.0c00688 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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