6VZM
Crystal structure of human PPARgamma ligand binding domain Y473E mutant in complex with Darglitazone
Summary for 6VZM
| Entry DOI | 10.2210/pdb6vzm/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, (5Z)-5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methylidene)-1,3-thiazolidine-2,4-dione (3 entities in total) |
| Functional Keywords | nuclear receptors, tzds, drug design, therapeutic targets, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 63667.85 |
| Authors | Shang, J.,Kojetin, D.J. (deposition date: 2020-02-28, release date: 2021-03-03, Last modification date: 2023-10-11) |
| Primary citation | Shang, J.,Kojetin, D.J. Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29:940-950.e4, 2021 Cited by PubMed: 33713599DOI: 10.1016/j.str.2021.02.006 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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