6VXU

Structure of Human Vaccinia-related Kinase 1 (VRK1) bound to ACH471

6VXU の概要

• エントリーDOI: 10.2210/pdb6vxu/pdb
• 分子名称: Serine/threonine-protein kinase VRK1, (7R)-8-(cyclopropylmethyl)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: protein kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 167587.05

構造登録者

dos Reis, C.V.,Dutra, L.A.,Gama, F.H.,Mascarello, A.,Azevedo, H.,Guimaraes, C.R.,Massirer, K.B.,Arruda, P.,Edwards, A.M.,Counago, R.M.,Structural Genomics Consortium (SGC) (登録日: 2020-02-24, 公開日: 2021-03-03, 最終更新日: 2023-10-11)

• 主引用文献: Guimaraes, C.R.,Counago, R.M.; Structure of Human Vaccinia-related Kinase 1 (VRK1) bound to ACH471; To Be Published,

実験手法

X-RAY DIFFRACTION (2 Å)