6VVT

Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and antibiotic Sorangicin

Summary for 6VVT

Entry DOI	10.2210/pdb6vvt/pdb
Descriptor	RNA polymerase-binding protein RbpA, 1,2-ETHANEDIOL, ZINC ION, ... (13 entities in total)
Functional Keywords	dna binding, antibiotic, transcription, transferase-dna-antibiotic complex, transferase/dna/antibiotic
Biological source	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) More
Total number of polymer chains	9
Total formula weight	446894.86
Authors	Lilic, M.,Darst, S.A.,Campbell, E.A. (deposition date: 2020-02-18, release date: 2020-10-21, Last modification date: 2023-10-11)
Primary citation	Lilic, M.,Chen, J.,Boyaci, H.,Braffman, N.,Hubin, E.A.,Herrmann, J.,Muller, R.,Mooney, R.,Landick, R.,Darst, S.A.,Campbell, E.A. The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117:30423-30432, 2020 Cited by PubMed: 33199626 DOI: 10.1073/pnas.2013706117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.901 Å)

Structure validation