6VV3

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1358

6VV3 の概要

• エントリーDOI: 10.2210/pdb6vv3/pdb
• 分子名称: N-acetyltransferase Eis, 2-[(4-amino-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(piperidin-1-yl)ethyl]acetamide, DIMETHYL SULFOXIDE, ... (7 entities in total)
• 機能のキーワード: acetyltransferase, resistance, aminoglycoside, competitive, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46876.06

構造登録者

Punetha, A.,Hou, C.,Ngo, H.X.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2020-02-16, 公開日: 2020-06-03, 最終更新日: 2023-10-11)

• 主引用文献: Punetha, A.,Ngo, H.X.,Holbrook, S.Y.L.,Green, K.D.,Willby, M.J.,Bonnett, S.A.,Krieger, K.,Dennis, E.K.,Posey, J.E.,Parish, T.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis.; Acs Chem.Biol., 15:1581-1594, 2020; PubMed: 32421305; DOI: 10.1021/acschembio.0c00184

実験手法

X-RAY DIFFRACTION (2.4 Å)