6VV1
Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT384
Summary for 6VV1
Entry DOI | 10.2210/pdb6vv1/pdb |
Descriptor | N-acetyltransferase Eis, 2-[(4-amino-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(piperidin-1-yl)ethyl]acetamide, DI(HYDROXYETHYL)ETHER, ... (8 entities in total) |
Functional Keywords | acetyltransferase, resistance, aminoglycoside, competitive, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 1 |
Total formula weight | 47346.63 |
Authors | Punetha, A.,Hou, C.,Ngo, H.X.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2020-02-16, release date: 2020-06-03, Last modification date: 2023-10-11) |
Primary citation | Punetha, A.,Ngo, H.X.,Holbrook, S.Y.L.,Green, K.D.,Willby, M.J.,Bonnett, S.A.,Krieger, K.,Dennis, E.K.,Posey, J.E.,Parish, T.,Tsodikov, O.V.,Garneau-Tsodikova, S. Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15:1581-1594, 2020 Cited by PubMed: 32421305DOI: 10.1021/acschembio.0c00184 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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