6VUU

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1347

Summary for 6VUU

• Entry DOI: 10.2210/pdb6vuu/pdb
• Descriptor: N-acetyltransferase Eis, (7S)-7-methyl-2-{[3-(piperidin-1-yl)propyl]sulfanyl}-7,8-dihydro[1]benzothieno[2,3-d]pyrimidin-4-amine, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: acetyltransferase, resistance, aminoglycoside, competitive, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 46990.55

Authors

Punetha, A.,Hou, C.,Ngo, H.X.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2020-02-16, release date: 2020-06-03, Last modification date: 2023-10-11)

• Primary citation: Punetha, A.,Ngo, H.X.,Holbrook, S.Y.L.,Green, K.D.,Willby, M.J.,Bonnett, S.A.,Krieger, K.,Dennis, E.K.,Posey, J.E.,Parish, T.,Tsodikov, O.V.,Garneau-Tsodikova, S.; Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis.; Acs Chem.Biol., 15:1581-1594, 2020; PubMed: 32421305; DOI: 10.1021/acschembio.0c00184

Experimental method

X-RAY DIFFRACTION (2.6 Å)