6VUQ

Crystal structure of CHIKV nsP3 macrodomain soaked with ADP-ribose

Summary for 6VUQ

• Entry DOI: 10.2210/pdb6vuq/pdb
• Descriptor: Nonstructural polyprotein, ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
• Functional Keywords: nsp3, macrodomain, viral protein
• Biological source: Chikungunya virus (CHIKV)
• Total number of polymer chains: 4
• Total formula weight: 76312.77

Authors

Wu, M. (deposition date: 2020-02-16, release date: 2021-01-13, Last modification date: 2023-10-11)

• Primary citation: Zhang, S.,Garzan, A.,Haese, N.,Bostwick, R.,Martinez-Gzegozewska, Y.,Rasmussen, L.,Streblow, D.N.,Haise, M.T.,Pathak, A.K.,Augelli-Szafran, C.E.,Wu, M.; Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.; Plos One, 16:e0245013-e0245013, 2021; PubMed: 33482665; DOI: 10.1371/journal.pone.0245013

Experimental method

X-RAY DIFFRACTION (1.64 Å)