6VUE

wild-type choline TMA lyase in complex with 1-methyl-1,2,3,6-tetrahydropyridin-3-ol

6VUE の概要

• エントリーDOI: 10.2210/pdb6vue/pdb
• 分子名称: Choline trimethylamine-lyase, SODIUM ION, (3S)-1-methyl-1,2,3,6-tetrahydropyridin-3-ol, ... (4 entities in total)
• 機能のキーワード: choline-tma lyase, microbiome choline cutc inhibitor, lyase, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Desulfovibrio alaskensis (strain G20)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 183444.55

構造登録者

Ortega, M.A.,Drennan, C.L. (登録日: 2020-02-15, 公開日: 2020-11-04, 最終更新日: 2023-10-11)

• 主引用文献: Bollenbach, M.,Ortega, M.,Orman, M.,Drennan, C.L.,Balskus, E.P.; Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.; Acs Med.Chem.Lett., 11:1980-1985, 2020; PubMed: 33062182; DOI: 10.1021/acsmedchemlett.0c00005

実験手法

X-RAY DIFFRACTION (2.28 Å)