6VTY

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM483

6VTY の概要

• エントリーDOI: 10.2210/pdb6vty/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, ethyl 3,5-dimethyl-4-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrrole-2-carboxylate, FLAVIN MONONUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, mitochondria, alpha-beta barrel
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 199538.27

構造登録者

Deng, X.,Phillips, M. (登録日: 2020-02-13, 公開日: 2020-04-22, 最終更新日: 2023-10-11)

• 主引用文献: Kokkonda, S.,Deng, X.,White, K.L.,El Mazouni, F.,White, J.,Shackleford, D.M.,Katneni, K.,Chiu, F.C.K.,Barker, H.,McLaren, J.,Crighton, E.,Chen, G.,Angulo-Barturen, I.,Jimenez-Diaz, M.B.,Ferrer, S.,Huertas-Valentin, L.,Martinez-Martinez, M.S.,Lafuente-Monasterio, M.J.,Chittimalla, R.,Shahi, S.P.,Wittlin, S.,Waterson, D.,Burrows, J.N.,Matthews, D.,Tomchick, D.,Rathod, P.K.,Palmer, M.J.,Charman, S.A.,Phillips, M.A.; Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.; J.Med.Chem., 63:4929-4956, 2020; PubMed: 32248693; DOI: 10.1021/acs.jmedchem.0c00311

実験手法

X-RAY DIFFRACTION (1.78 Å)