6VS5

Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (fragment 1)

6VS5 の概要

• エントリーDOI: 10.2210/pdb6vs5/pdb
• 分子名称: Dihydrofolate reductase, COBALT (II) ION, 5-methyl-1-phenyl-pyrazole-4-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: folate pathway, biosynthetic protein
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38489.04

構造登録者

Ribeiro, J.A.,Tyrakis, P.,Blundell, T.,Dias, M.V.B. (登録日: 2020-02-10, 公開日: 2020-07-15, 最終更新日: 2023-10-11)

• 主引用文献: Ribeiro, J.A.,Hammer, A.,Libreros-Zuniga, G.A.,Chavez-Pacheco, S.M.,Tyrakis, P.,de Oliveira, G.S.,Kirkman, T.,El Bakali, J.,Rocco, S.A.,Sforca, M.L.,Parise-Filho, R.,Coyne, A.G.,Blundell, T.L.,Abell, C.,Dias, M.V.B.; Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis.; Acs Infect Dis., 6:2192-2201, 2020; PubMed: 32603583; DOI: 10.1021/acsinfecdis.0c00263

実験手法

X-RAY DIFFRACTION (1.758 Å)