6VRV
Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model
Summary for 6VRV
Entry DOI | 10.2210/pdb6vrv/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, 4-chloro-1-{(1S)-1-[(3S)-3-fluoropyrrolidin-3-yl]ethyl}-3-methyl-1H-pyrrolo[2,3-b]pyridine-6-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | inhibitor complex, oncoprotein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32021.75 |
Authors | Barberis, C.E.,Batchelor, J.D.,Liu, J. (deposition date: 2020-02-10, release date: 2020-11-04, Last modification date: 2023-10-11) |
Primary citation | Barberis, C.,Erdman, P.,Czekaj, M.,Fire, L.,Pribish, J.,Tserlin, E.,Maniar, S.,Batchelor, J.D.,Liu, J.,Patel, V.F.,Hebert, A.,Levit, M.,Wang, A.,Sun, F.,Huang, S.A. Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg.Med.Chem.Lett., 30:127625-127625, 2020 Cited by PubMed: 33096160DOI: 10.1016/j.bmcl.2020.127625 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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