6VQF

CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244- 487)-L6-SRC1(678-692)) IN COMPLEX WITH AN INVERSE AGONIST

6VQF の概要

• エントリーDOI: 10.2210/pdb6vqf/pdb
• 分子名称: Nuclear receptor ROR-gamma, (1R,3S,4R)-4-[(3aR,9bR)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl]-3-methylcyclohexane-1-carboxylic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: rorgt, nuclear hormone receptor, ligand-binding domain, inverse agonist, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33646.62

構造登録者

Sack, J.S. (登録日: 2020-02-05, 公開日: 2020-04-08, 最終更新日: 2023-10-11)

• 主引用文献: Cherney, R.J.,Cornelius, L.A.M.,Srivastava, A.,Weigelt, C.A.,Marcoux, D.,Duan, J.J.,Shi, Q.,Batt, D.G.,Liu, Q.,Yip, S.,Wu, D.R.,Ruzanov, M.,Sack, J.,Khan, J.,Wang, J.,Yarde, M.,Cvijic, M.E.,Mathur, A.,Li, S.,Shuster, D.,Khandelwal, P.,Borowski, V.,Xie, J.,Obermeier, M.,Fura, A.,Stefanski, K.,Cornelius, G.,Tino, J.A.,Macor, J.E.,Salter-Cid, L.,Denton, R.,Zhao, Q.,Carter, P.H.,Dhar, T.G.M.; Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR gamma t Inverse Agonist.; Acs Med.Chem.Lett., 11:1221-1227, 2020; PubMed: 32551004; DOI: 10.1021/acsmedchemlett.0c00063

実験手法

X-RAY DIFFRACTION (2 Å)