6VPM

TPX2 residues 7-20 fused to Aurora A residues 116-389 with C290 disulfide bonded to compound 8-34, and in complex with AMP-PNP

Summary for 6VPM

Entry DOI	10.2210/pdb6vpm/pdb
Descriptor	TPX2 fragment - Aurora A kinase domain fusion, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ... (6 entities in total)
Functional Keywords	ser/thr kinase, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	69671.49
Authors	Lim, D.C.,Yaffe, M.B. (deposition date: 2020-02-03, release date: 2020-08-05, Last modification date: 2024-04-03)
Primary citation	Lim, D.C.,Joukov, V.,Rettenmaier, T.J.,Kumagai, A.,Dunphy, W.G.,Wells, J.A.,Yaffe, M.B. Redox priming promotes Aurora A activation during mitosis. Sci.Signal., 13:-, 2020 Cited by PubMed: 32694171 DOI: 10.1126/scisignal.abb6707 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.58 Å)

Structure validation