6VPF

Estrogen Receptor Alpha Ligand Binding Domain in Complex with the Selective Estrogen Receptor Modulator Clomiphene

6VPF の概要

• エントリーDOI: 10.2210/pdb6vpf/pdb
• 分子名称: Estrogen receptor, Clomifene (3 entities in total)
• 機能のキーワード: breast cancer, hormone, selective estrogen receptor modulator, antiestrogen, alpha helical bundle, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122412.64

構造登録者

Fanning, S.W.,Greene, G.L. (登録日: 2020-02-03, 公開日: 2020-09-16, 最終更新日: 2023-10-11)

• 主引用文献: Hosfield, D.J.,Weber, S.,Li, N.S.,Suavage, M.,Joiner, C.F.,Hancock, G.R.,Sullivan, E.A.,Ndukwe, E.,Han, R.,Cush, S.,Laine, M.,Mader, S.C.,Greene, G.L.,Fanning, S.W.; Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.; Elife, 11:-, 2022; PubMed: 35575456; DOI: 10.7554/eLife.72512

実験手法

X-RAY DIFFRACTION (1.6 Å)