6VP8

Cryo-EM structure of the C-terminal half of the Parkinson's Disease-linked protein Leucine Rich Repeat Kinase 2 (LRRK2)

Summary for 6VP8

Entry DOI	10.2210/pdb6vp8/pdb
EMDB information	21250
Descriptor	Leucine-rich repeat serine/threonine-protein kinase 2 (3 entities in total)
Functional Keywords	kinase, gtpase, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	209047.02
Authors	Leschziner, A.,Deniston, C.,Lahiri, I. (deposition date: 2020-02-01, release date: 2020-08-26, Last modification date: 2022-03-16)
Primary citation	Deniston, C.K.,Salogiannis, J.,Mathea, S.,Snead, D.M.,Lahiri, I.,Matyszewski, M.,Donosa, O.,Watanabe, R.,Bohning, J.,Shiau, A.K.,Knapp, S.,Villa, E.,Reck-Peterson, S.L.,Leschziner, A.E. Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature, 588:344-349, 2020 Cited by PubMed: 32814344 DOI: 10.1038/s41586-020-2673-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation