6VP6
Cryo-EM structure of the C-terminal half of the Parkinson's Disease-linked protein Leucine Rich Repeat Kinase 2 (LRRK2)
Summary for 6VP6
Entry DOI | 10.2210/pdb6vp6/pdb |
EMDB information | 21250 |
Descriptor | Leucine-rich repeat serine/threonine-protein kinase 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION (3 entities in total) |
Functional Keywords | kinase, gtpase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 411298.33 |
Authors | Leschziner, A.,Deniston, C.,Lahiri, I. (deposition date: 2020-02-01, release date: 2020-08-26, Last modification date: 2020-12-23) |
Primary citation | Deniston, C.K.,Salogiannis, J.,Mathea, S.,Snead, D.M.,Lahiri, I.,Matyszewski, M.,Donosa, O.,Watanabe, R.,Bohning, J.,Shiau, A.K.,Knapp, S.,Villa, E.,Reck-Peterson, S.L.,Leschziner, A.E. Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature, 588:344-349, 2020 Cited by PubMed: 32814344DOI: 10.1038/s41586-020-2673-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.47 Å) |
Structure validation
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