6VOT

Crystal structure of Pseudomonas aerugonisa PBP3 complexed to gamma-lactam YU253434

6VOT の概要

• エントリーDOI: 10.2210/pdb6vot/pdb
• 分子名称: Peptidoglycan D,D-transpeptidase FtsI, 1-[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6 -dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid (3 entities in total)
• 機能のキーワード: inhibitor complex, penicillin-binding protein, antibiotic, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 59018.08

構造登録者

van den Akker, F. (登録日: 2020-01-31, 公開日: 2020-05-13, 最終更新日: 2023-10-11)

• 主引用文献: Goldberg, J.A.,Nguyen, H.,Kumar, V.,Spencer, E.J.,Hoyer, D.,Marshall, E.K.,Cmolik, A.,O'Shea, M.,Marshall, S.H.,Hujer, A.M.,Hujer, K.M.,Rudin, S.D.,Domitrovic, T.N.,Bethel, C.R.,Papp-Wallace, K.M.,Logan, L.K.,Perez, F.,Jacobs, M.R.,van Duin, D.,Kreiswirth, B.M.,Bonomo, R.A.,Plummer, M.S.,van den Akker, F.; A gamma-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli.; J.Med.Chem., 63:5990-6002, 2020; PubMed: 32420736; DOI: 10.1021/acs.jmedchem.0c00255

実験手法

X-RAY DIFFRACTION (2.4 Å)