6VNZ

NMR solution structure of tamapin, mutant K20A

6VNZ の概要

• エントリーDOI: 10.2210/pdb6vnz/pdb
• NMR情報: BMRB: 30719
• 分子名称: Potassium channel toxin alpha-KTx 5.4 (1 entity in total)
• 機能のキーワード: tamapin mutant, csalpha/beta, sk channels, toxin
• 由来する生物種: Hottentotta tamulus (Eastern Indian scorpion)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3412.08

構造登録者

del Rio Portilla, F.,Melchor Meneses, C.M.,Mayorga Flores, M. (登録日: 2020-01-29, 公開日: 2020-07-29, 最終更新日: 2024-11-06)

主引用文献

Mayorga-Flores, M.,Chantome, A.,Melchor-Meneses, C.M.,Domingo, I.,Titaux-Delgado, G.A.,Galindo-Murillo, R.,Vandier, C.,Del Rio-Portilla, F.
Novel Blocker of Onco SK3 Channels Derived from Scorpion Toxin Tamapin and Active against Migration of Cancer Cells.
Acs Med.Chem.Lett., 11:1627-1633, 2020

PubMed Abstract: Peptide-based therapy against cancer is a field of great interest for biomedical developments. Since it was shown that SK3 channels promote cancer cell migration and metastatic development, we started using these channels as targets for the development of antimetastatic drugs. Particularly, tamapin (a peptide found in the venom of the scorpion ) is the most specific toxin against the SK2 channel currently known. Considering this fact, we designed diverse tamapin mutants based on three different hypotheses to discover a new potent molecule to block SK3 channels. We performed studies to evaluate this new toxin derivative inhibitor of cancer cell migration. Our results can be used to generate a new tamapin-based therapy against cancer cells that express SK3 channels.

PubMed: 32832033
DOI: 10.1021/acsmedchemlett.0c00300

実験手法

SOLUTION NMR