6VNQ

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Bishydroxamic Acid Based Inhibitor

Summary for 6VNQ

Entry DOI	10.2210/pdb6vnq/pdb
Descriptor	Polyamine deacetylase HDAC10, N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	histone deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	75838.64
Authors	Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2020-01-29, release date: 2020-05-13, Last modification date: 2023-10-11)
Primary citation	Morgen, M.,Steimbach, R.R.,Geraldy, M.,Hellweg, L.,Sehr, P.,Ridinger, J.,Witt, O.,Oehme, I.,Herbst-Gervasoni, C.J.,Osko, J.D.,Porter, N.J.,Christianson, D.W.,Gunkel, N.,Miller, A.K. Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. Chemmedchem, 15:1163-1174, 2020 Cited by PubMed: 32348628 DOI: 10.1002/cmdc.202000149 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation