6VNQ

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Bishydroxamic Acid Based Inhibitor

6VNQ の概要

• エントリーDOI: 10.2210/pdb6vnq/pdb
• 分子名称: Polyamine deacetylase HDAC10, N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: histone deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Danio rerio (Zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75838.64

構造登録者

Herbst-Gervasoni, C.J.,Christianson, D.W. (登録日: 2020-01-29, 公開日: 2020-05-13, 最終更新日: 2023-10-11)

• 主引用文献: Morgen, M.,Steimbach, R.R.,Geraldy, M.,Hellweg, L.,Sehr, P.,Ridinger, J.,Witt, O.,Oehme, I.,Herbst-Gervasoni, C.J.,Osko, J.D.,Porter, N.J.,Christianson, D.W.,Gunkel, N.,Miller, A.K.; Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.; Chemmedchem, 15:1163-1174, 2020; PubMed: 32348628; DOI: 10.1002/cmdc.202000149

実験手法

X-RAY DIFFRACTION (2.05 Å)