6VLV

Factor XIa in complex with compound 11

Summary for 6VLV

Entry DOI	10.2210/pdb6vlv/pdb
Descriptor	Coagulation factor XIa light chain, CITRATE ANION, 1-carbamimidamido-4-chloro-N-[(2R)-3-methyl-1-(morpholin-4-yl)-1-oxobutan-2-yl]isoquinoline-7-sulfonamide, ... (4 entities in total)
Functional Keywords	hydrolase, serine protease, coagulation factor, hydrolase-hydrolase inhibitor complex, blood clotting
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	27703.65
Authors	Lesburg, C.A. (deposition date: 2020-01-27, release date: 2020-05-06, Last modification date: 2020-10-07)
Primary citation	Yan, X.C.,Sanders, J.M.,Gao, Y.D.,Tudor, M.,Haidle, A.M.,Klein, D.J.,Converso, A.,Lesburg, C.A.,Zang, Y.,Wood, H.B. Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery. J.Chem.Inf.Model., 60:4144-4152, 2020 Cited by PubMed: 32309939 DOI: 10.1021/acs.jcim.0c00113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation