6VLV

Factor XIa in complex with compound 11

6VLV の概要

• エントリーDOI: 10.2210/pdb6vlv/pdb
• 分子名称: Coagulation factor XIa light chain, CITRATE ANION, 1-carbamimidamido-4-chloro-N-[(2R)-3-methyl-1-(morpholin-4-yl)-1-oxobutan-2-yl]isoquinoline-7-sulfonamide, ... (4 entities in total)
• 機能のキーワード: hydrolase, serine protease, coagulation factor, hydrolase-hydrolase inhibitor complex, blood clotting
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27703.65

構造登録者

Lesburg, C.A. (登録日: 2020-01-27, 公開日: 2020-05-06, 最終更新日: 2020-10-07)

• 主引用文献: Yan, X.C.,Sanders, J.M.,Gao, Y.D.,Tudor, M.,Haidle, A.M.,Klein, D.J.,Converso, A.,Lesburg, C.A.,Zang, Y.,Wood, H.B.; Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.; J.Chem.Inf.Model., 60:4144-4152, 2020; PubMed: 32309939; DOI: 10.1021/acs.jcim.0c00113

実験手法

X-RAY DIFFRACTION (1.72 Å)