6VJ3

Carbonic Anhydrase II in complex with pyrimidine-based inhibitor

6VJ3 の概要

• エントリーDOI: 10.2210/pdb6vj3/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-(4-sulfamoylphenyl)acetamide, ... (5 entities in total)
• 機能のキーワード: ca ii, sulfonamide, pyrimidine, inhibitor, cancer, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29552.60

構造登録者

Lomelino, C.L.,McKenna, R. (登録日: 2020-01-14, 公開日: 2020-03-11, 最終更新日: 2023-10-11)

• 主引用文献: Petreni, A.,Bonardi, A.,Lomelino, C.,Osman, S.M.,ALOthman, Z.A.,Eldehna, W.M.,El-Haggar, R.,McKenna, R.,Nocentini, A.,Supuran, C.T.; Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.; Eur.J.Med.Chem., 190:112112-112112, 2020; PubMed: 32044580; DOI: 10.1016/j.ejmech.2020.112112

実験手法

X-RAY DIFFRACTION (1.35 Å)