6VIX
BRD4_Bromodomain2 complex with pyrrolopyridone compound 18
6VIX の概要
エントリーDOI | 10.2210/pdb6vix/pdb |
分子名称 | Bromodomain-containing protein 4, 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (3 entities in total) |
機能のキーワード | bromodomain, signaling protein |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 53461.94 |
構造登録者 | |
主引用文献 | Sheppard, G.S.,Wang, L.,Fidanze, S.D.,Hasvold, L.A.,Liu, D.,Pratt, J.K.,Park, C.H.,Longenecker, K.,Qiu, W.,Torrent, M.,Kovar, P.J.,Bui, M.,Faivre, E.,Huang, X.,Lin, X.,Wilcox, D.,Zhang, L.,Shen, Y.,Albert, D.H.,Magoc, T.J.,Rajaraman, G.,Kati, W.M.,McDaniel, K.F. Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63:5585-5623, 2020 Cited by PubMed: 32324999DOI: 10.1021/acs.jmedchem.0c00628 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.116 Å) |
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