6VH4

Wild type EGFR in complex with LN2380

6VH4 の概要

• エントリーDOI: 10.2210/pdb6vh4/pdb
• 分子名称: Epidermal growth factor receptor, N-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1H-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide (3 entities in total)
• 機能のキーワード: epidermal growth factor receptor, inhibitor, cancer, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37793.67

構造登録者

Heppner, D.E.,Eck, M.J. (登録日: 2020-01-09, 公開日: 2020-04-22, 最終更新日: 2023-10-11)

• 主引用文献: Heppner, D.E.,Gunther, M.,Wittlinger, F.,Laufer, S.A.,Eck, M.J.; Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.; J.Med.Chem., 63:4293-4305, 2020; PubMed: 32243152; DOI: 10.1021/acs.jmedchem.0c00200

実験手法

X-RAY DIFFRACTION (2.8 Å)