6VDM

HCV NS3/4A protease A156T, D168E double mutant in complex with glecaprevir

6VDM の概要

• エントリーDOI: 10.2210/pdb6vdm/pdb
• 分子名称: Non-structural protein 4A, Serine protease NS3, ZINC ION, (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclop ropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17, 3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide, ... (6 entities in total)
• 機能のキーワード: hcv protease, ns34a protease, glecaprevir, viral protein, hydrolase
• 由来する生物種: Hepatitis C virus genotype 1a (isolate 1) (HCV); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22848.00

構造登録者

Timm, J.,Schiffer, C.A. (登録日: 2019-12-27, 公開日: 2020-12-30, 最終更新日: 2023-10-11)

• 主引用文献: Timm, J.,Zephyr, J.,Hou, S.,Kurt Yilmaz, N.,Schiffer, C.A.; RAS at position 156 of HCV NS3/4A protease abolish inhibition by current HCV drugs; To Be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)