6VC8

Crystal structure of wild-type KRAS4b(1-169) in complex with GMPPNP and Mg ion

Summary for 6VC8

• Entry DOI: 10.2210/pdb6vc8/pdb
• Descriptor: GTPase KRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: kras, ras, kras4b, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 59625.94

Authors

Tran, T.H.,Davies, D.R.,Edwards, T.E.,Simanshu, D.K. (deposition date: 2019-12-20, release date: 2021-02-10, Last modification date: 2023-10-11)

• Primary citation: Ingolfsson, H.I.,Neale, C.,Carpenter, T.S.,Shrestha, R.,Lopez, C.A.,Tran, T.H.,Oppelstrup, T.,Bhatia, H.,Stanton, L.G.,Zhang, X.,Sundram, S.,Di Natale, F.,Agarwal, A.,Dharuman, G.,Kokkila Schumacher, S.I.L.,Turbyville, T.,Gulten, G.,Van, Q.N.,Goswami, D.,Jean-Francois, F.,Agamasu, C.,Hettige, J.J.,Travers, T.,Sarkar, S.,Surh, M.P.,Yang, Y.,Moody, A.,Liu, S.,Van Essen, B.C.,Voter, A.F.,Ramanathan, A.,Hengartner, N.W.,Simanshu, D.K.,Stephen, A.G.,Bremer, P.T.,Gnanakaran, S.,Glosli, J.N.,Lightstone, F.C.,McCormick, F.,Nissley, D.V.,Streitz, F.H.; Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.; Proc.Natl.Acad.Sci.USA, 119:-, 2022; PubMed: 34983849; DOI: 10.1073/pnas.2113297119

Experimental method

X-RAY DIFFRACTION (2.5 Å)